منابع مشابه
miRNA and tropism of human parvovirus B19
Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpr...
متن کاملParvovirus B19.
N Engl J Med 2004;350:586-97. Copyright © 2004 Massachusetts Medical Society. vonne cossart, an australian virologist working in london in the mid-1970s, noted an anomalous reaction of a normal blood donor’s serum (occupying position 19 in plate B) in an assay for hepatitis B. When Cossart excised the line of antigen–antibody precipitation, she saw the particles shown in Figure 1A, and in this ...
متن کاملThe structure of human parvovirus B19.
Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3.5-A resolution by x-ray crystallography and, to our knowledge, represents the first near-atomic structure of an Erythrovirus. The polypeptide fold of the major capsid protein VP2 is a "jelly roll" with a beta-barrel motif similar to tha...
متن کاملHigh-sensitivity PCR detection of parvovirus B19 in plasma.
Parvovirus B19 (B19) is a human pathogen transmitted to susceptible individuals via respiratory secretions and contaminated blood or blood products. B19 levels in pooled plasma of less than 10(4) genome equivalents/ml may not be infectious, while those greater than 10(7)/ml are capable of transmitting infection. A World Health Organization (WHO) B19 DNA international standard has been recently ...
متن کاملHuman parvovirus B19 and pediatric rheumatologic disease
Purpose Human Parvovirus B19 causes a self-limited febrile illness with a characteristic exanthem and occasional acute arthritis. B19 infection has also been associated with multiple rheumatic diseases. Reports indicate that in patients with positive B19 PCR up to ~1/3 have negative IgM and positive IgG to B19. However little is known about how these findings might relate to rheumatologic sympt...
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ژورنال
عنوان ژورنال: Vox Sanguinis
سال: 2003
ISSN: 0042-9007
DOI: 10.1046/j.1423-0410.2003.00301.x-i1